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Catalog Number:
41173
CAS Number:
100165-88-6
S-(-)-TolBINAP
Purity:
≥ 99% (Chiral purity)
Synonym(s):
(S-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
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Product Information

(S)-(-)-TolBINAP is a highly effective chiral ligand widely utilized in asymmetric synthesis and catalysis. This compound is recognized for its ability to facilitate enantioselective reactions, making it invaluable in the production of pharmaceuticals and fine chemicals. Its unique structure, featuring a naphthalene backbone and bis(4-methylphenyl)phosphane groups, enhances its reactivity and selectivity, allowing researchers to achieve high yields of desired enantiomers.

In practical applications, (S)-(-)-TolBINAP has been employed in various catalytic processes, including the synthesis of chiral alcohols and amines, which are crucial intermediates in drug development. Its effectiveness in promoting reactions under mild conditions sets it apart from other ligands, providing a significant advantage in terms of operational simplicity and product purity. Researchers and industry professionals can leverage (S)-(-)-TolBINAP to streamline their synthetic pathways, reduce waste, and improve overall efficiency in their chemical processes.

Synonyms
(S-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
CAS Number
100165-88-6
Purity
≥ 99% (Chiral purity)
Molecular Formula
C48H40P2
Molecular Weight
678.8
MDL Number
MFCD01311709
PubChem ID
4189906
Melting Point
258 °C (Lit.)
Appearance
White to off-white crystal
Conditions
Store at RT
General Information
Synonyms
(S-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
CAS Number
100165-88-6
Purity
≥ 99% (Chiral purity)
Molecular Formula
C48H40P2
Molecular Weight
678.8
MDL Number
MFCD01311709
PubChem ID
4189906
Melting Point
258 °C (Lit.)
Appearance
White to off-white crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(S)-(-)-TolBINAP is widely utilized in research focused on:

  • Asymmetric Synthesis: This compound serves as a chiral ligand in asymmetric catalysis, enabling the production of enantiomerically pure compounds, which is crucial in pharmaceuticals.
  • Pharmaceutical Development: Its application in drug synthesis helps create specific drug forms that can enhance efficacy and reduce side effects, particularly in the development of chiral drugs.
  • Organic Chemistry Research: Researchers use it to explore new synthetic pathways and reactions, making it a valuable tool in academic and industrial laboratories.
  • Material Science: It plays a role in the development of advanced materials, such as polymers and nanomaterials, due to its unique chemical properties.
  • Environmental Chemistry: The compound is also investigated for its potential in catalyzing reactions that can lead to greener chemical processes, reducing waste and energy consumption.

Citations