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Catalog Number:
11435
CAS Number:
2507-61-1
trans-4-Fluoro-L-proline
Purity:
≥ 97% (HPLC)
Synonym(s):
trans-4-Fluoro-L-Pro-OH, (2S,4R-4-Fluoro-pyrrolidine-2-carboxylic acid
Documents
$86.23 /100MG
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Product Information

trans-4-Fluoro-L-proline is a valuable amino acid derivative that has garnered attention in the fields of medicinal chemistry and biochemistry. This compound is recognized for its unique fluorinated structure, which enhances its stability and bioactivity compared to non-fluorinated analogs. Its ability to act as a building block in the synthesis of peptide-based drugs makes it particularly relevant for researchers focused on developing novel therapeutics. Additionally, trans-4-Fluoro-L-proline has been utilized in the design of inhibitors for various enzymes, showcasing its potential in drug discovery and development.

The compound's distinctive properties enable it to serve as a chiral auxiliary in asymmetric synthesis, providing researchers with an effective tool for creating enantiomerically pure compounds. Its applications extend to the pharmaceutical industry, where it can be integrated into the development of treatments for neurological disorders and cancer. With its promising characteristics, trans-4-Fluoro-L-proline stands out as a versatile compound that can significantly contribute to advancements in drug formulation and synthesis.

Synonyms
trans-4-Fluoro-L-Pro-OH, (2S,4R-4-Fluoro-pyrrolidine-2-carboxylic acid
CAS Number
2507-61-1
Purity
≥ 97% (HPLC)
Molecular Formula
C5H8FNO2
Molecular Weight
133.12
MDL Number
MFCD02683982
PubChem ID
560340
Melting Point
229.2 °C (dec)
Appearance
Off-white solid
Optical Rotation
[a]D27 = -78 ± 2º (C=1.3 in H2O)
Conditions
Store at 0-8°C
General Information
Synonyms
trans-4-Fluoro-L-Pro-OH, (2S,4R-4-Fluoro-pyrrolidine-2-carboxylic acid
CAS Number
2507-61-1
Purity
≥ 97% (HPLC)
Molecular Formula
C5H8FNO2
Molecular Weight
133.12
MDL Number
MFCD02683982
PubChem ID
560340
Melting Point
229.2 °C (dec)
Appearance
Off-white solid
Optical Rotation
[a]D27 = -78 ± 2º (C=1.3 in H2O)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

trans-4-Fluoro-L-proline is widely utilized in research focused on

  • Pharmaceutical Development: This compound serves as a valuable building block in the synthesis of various pharmaceuticals, particularly in the development of peptide-based drugs that target specific biological pathways.
  • Protein Engineering: Researchers use trans-4-Fluoro-L-proline to modify proteins, enhancing their stability and activity. This modification can lead to improved therapeutic proteins with better efficacy.
  • Biochemical Studies: It is employed in studies examining protein folding and stability, helping scientists understand how structural changes affect function, which is crucial in drug design.
  • Material Science: The compound is explored in the development of novel materials, particularly in creating polymers with unique properties, such as increased flexibility and strength.
  • Research on Fluorinated Amino Acids: Its use in studies of fluorinated amino acids provides insights into their biological roles and potential applications in medicinal chemistry, offering advantages over non-fluorinated counterparts in terms of metabolic stability.

Citations