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Catalog Number:
41653
CAS Number:
61478-26-0
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine
Purity:
≥ 96% (GC)
Synonym(s):
(2S,4R)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine, N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-prolinol, N-Boc-trans-4-hydroxy-L-prolinol, tert-Butyl(2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
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Product Information

(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine is a versatile compound widely utilized in the field of organic synthesis and pharmaceutical development. This compound, characterized by its unique pyrrolidine structure, serves as a valuable intermediate in the synthesis of various bioactive molecules. Its hydroxymethyl and hydroxy functional groups enhance its reactivity, making it an ideal candidate for further modifications in drug design and development. Researchers appreciate its role in the synthesis of peptide analogs and other complex organic compounds, which are crucial in medicinal chemistry.

In addition to its synthetic applications, this compound is recognized for its potential in the development of chiral catalysts and ligands, contributing to advancements in asymmetric synthesis. Its stability and ease of handling make it a preferred choice for laboratories focused on innovative research. The compound's ability to facilitate the creation of diverse chemical entities underscores its importance in both academic and industrial settings, providing researchers with a reliable tool for exploring new therapeutic avenues.

Synonyms
(2S,4R)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine, N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-prolinol, N-Boc-trans-4-hydroxy-L-prolinol, tert-Butyl(2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS Number
61478-26-0
Purity
≥ 96% (GC)
Molecular Formula
C10H19NO4
Molecular Weight
217.27
MDL Number
MFCD02094386
PubChem ID
4204845
Melting Point
82 - 87 °C
Appearance
White to yellow to orange powder to lump
Optical Rotation
[a]20D = -47 to -44 ° (C = 1 in CHCl3)
Conditions
Store at RT
General Information
Synonyms
(2S,4R)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine, N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-prolinol, N-Boc-trans-4-hydroxy-L-prolinol, tert-Butyl(2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS Number
61478-26-0
Purity
≥ 96% (GC)
Molecular Formula
C10H19NO4
Molecular Weight
217.27
MDL Number
MFCD02094386
PubChem ID
4204845
Melting Point
82 - 87 °C
Appearance
White to yellow to orange powder to lump
Optical Rotation
[a]20D = -47 to -44 ° (C = 1 in CHCl3)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine is widely utilized in research focused on:

  • Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting neurological disorders.
  • Peptide Synthesis: It is commonly used in solid-phase peptide synthesis, enhancing the yield and purity of peptide products, which are crucial in drug formulation.
  • Biochemical Research: Researchers employ this compound in studies related to enzyme inhibition and protein interactions, aiding in the understanding of biological processes.
  • Cosmetic Formulations: The compound's properties make it suitable for use in cosmetic products, providing moisturizing benefits and improving skin texture.
  • Material Science: It is utilized in the development of biodegradable polymers, contributing to sustainable materials that reduce environmental impact.

Citations