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Catalog Number:
38096
CAS Number:
55661-38-6
Nimustine hydrochloride
Synonym(s):
ACNU, 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea hydrochloride
Hazmat
Documents
$267.20 /1G
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Product Information

Nimustine hydrochloride is a potent chemotherapeutic agent primarily utilized in the treatment of various cancers, particularly glioblastoma and other brain tumors. This compound functions as an alkylating agent, disrupting the DNA replication process in cancer cells, which leads to cell death. Its unique structure, featuring a nitrosourea moiety, enhances its ability to cross the blood-brain barrier, making it especially effective for central nervous system malignancies. Researchers and healthcare professionals appreciate Nimustine hydrochloride for its targeted action and relatively favorable side effect profile compared to other chemotherapeutics.

In clinical settings, Nimustine hydrochloride is often administered in combination with other agents to enhance therapeutic efficacy and improve patient outcomes. Its application extends beyond oncology; ongoing research is exploring its potential in treating other conditions where targeted cell death is beneficial. With a focus on innovative cancer therapies, Nimustine hydrochloride remains a vital compound in the arsenal against resistant tumors, offering hope for improved survival rates in patients facing challenging diagnoses.

Synonyms
ACNU, 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea hydrochloride
CAS Number
55661-38-6
Molecular Formula
C9H13ClN6O2·HCl
Molecular Weight
309.15
MDL Number
MFCD01676942
PubChem ID
91657
Appearance
Solid
Conditions
Store at 2 - 8 °C
General Information
Synonyms
ACNU, 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea hydrochloride
CAS Number
55661-38-6
Molecular Formula
C9H13ClN6O2·HCl
Molecular Weight
309.15
MDL Number
MFCD01676942
PubChem ID
91657
Appearance
Solid
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nimustine hydrochloride is widely utilized in research focused on:

  • Cancer Treatment: Primarily used in oncology, it serves as a chemotherapeutic agent for treating brain tumors, particularly glioblastomas, offering targeted action against malignant cells.
  • Combination Therapy: Often employed in combination with other anticancer drugs, it enhances treatment efficacy and helps overcome drug resistance, providing a more comprehensive approach to cancer management.
  • Research in Drug Development: Used in preclinical studies to evaluate new drug formulations and delivery methods, helping researchers understand its pharmacodynamics and optimize therapeutic strategies.
  • Veterinary Medicine: Its applications extend to veterinary oncology, where it is used to treat tumors in animals, showcasing its versatility across species.
  • Clinical Trials: Frequently involved in clinical trials aimed at improving treatment protocols for various cancers, contributing to advancements in medical research and patient care.

Citations