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Catalog Number:
38090
CAS Number:
114-80-7
Neostigmine bromide
Purity:
≥ 99% (Assay by Titration)
Synonym(s):
(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide, (3-Hydroxyphenyl)trimethylammonium bromide dimethyl carbamate
Hazmat
Documents
$118.08 /5G
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Product Information

Neostigmine bromide is a potent reversible inhibitor of the enzyme acetylcholinesterase, making it a crucial compound in the treatment of myasthenia gravis and other neuromuscular disorders. This compound enhances the communication between nerves and muscles by increasing the levels of acetylcholine at the neuromuscular junction, thereby improving muscle strength and function. Its applications extend to the reversal of neuromuscular blockade induced by certain anesthetics, making it invaluable in surgical settings.

In addition to its therapeutic uses, neostigmine bromide is also employed in research settings to study cholinergic signaling and its implications in various neurological conditions. Its unique ability to cross the blood-brain barrier allows for potential applications in cognitive enhancement and neuroprotection. With a well-established safety profile and efficacy, neostigmine bromide stands out as a reliable choice for both clinical and research applications, offering significant benefits over other cholinesterase inhibitors.

Synonyms
(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide, (3-Hydroxyphenyl)trimethylammonium bromide dimethyl carbamate
CAS Number
114-80-7
Purity
≥ 99% (Assay by Titration)
Molecular Formula
C12H19BrN2O2
Molecular Weight
303.2
MDL Number
MFCD00011795
PubChem ID
8246
Melting Point
175 - 177 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide, (3-Hydroxyphenyl)trimethylammonium bromide dimethyl carbamate
CAS Number
114-80-7
Purity
≥ 99% (Assay by Titration)
Molecular Formula
C12H19BrN2O2
Molecular Weight
303.2
MDL Number
MFCD00011795
PubChem ID
8246
Melting Point
175 - 177 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Neostigmine bromide is widely utilized in research focused on

  • Medical Treatment: It is primarily used in the treatment of myasthenia gravis, a neuromuscular disorder. By inhibiting the breakdown of acetylcholine, it enhances muscle contraction and improves muscle strength.
  • Anesthesia: In surgical settings, neostigmine is employed to reverse the effects of muscle relaxants after surgery, helping patients regain muscle function more quickly and safely.
  • Research in Neuropharmacology: Researchers use it to study cholinergic signaling pathways and the effects of acetylcholine in the nervous system, contributing to the understanding of various neurological conditions.
  • Veterinary Medicine: It is also applied in veterinary practices for treating certain muscle disorders in animals, providing a critical tool for veterinarians in managing neuromuscular issues.
  • Pharmaceutical Development: Neostigmine bromide serves as a model compound in drug formulation studies, helping to develop new medications that target similar pathways, which can lead to advancements in treating related diseases.

Citations