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Catalog Number:
37933
CAS Number:
58-93-5
Hydrochlorothiazide
Purity:
≥ 97% (HPLC)
Synonym(s):
7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide, 6-Chloro-7-sulfamoyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide
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Product Information

Hydrochlorothiazide is a widely recognized thiazide diuretic, primarily utilized in the management of hypertension and edema associated with heart failure, liver cirrhosis, and renal disorders. This compound works by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased urine output and a reduction in blood pressure. Its efficacy in lowering blood pressure makes it a staple in cardiovascular therapy, often used in combination with other antihypertensive agents to enhance therapeutic outcomes.

In addition to its primary applications, Hydrochlorothiazide has been explored for its potential benefits in treating conditions such as diabetes insipidus and certain types of kidney stones, showcasing its versatility in clinical settings. Researchers and healthcare professionals appreciate its relatively low side effect profile compared to other diuretics, making it a preferred choice in long-term treatment plans. With its established role in improving patient outcomes, Hydrochlorothiazide remains an essential compound in both pharmaceutical formulations and clinical practice.

Synonyms
7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide, 6-Chloro-7-sulfamoyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide
CAS Number
58-93-5
Purity
≥ 97% (HPLC)
Molecular Formula
C7H8ClN3O4S2
Molecular Weight
297.73
MDL Number
MFCD00051765
PubChem ID
3639
Melting Point
268 - 270 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide, 6-Chloro-7-sulfamoyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide
CAS Number
58-93-5
Purity
≥ 97% (HPLC)
Molecular Formula
C7H8ClN3O4S2
Molecular Weight
297.73
MDL Number
MFCD00051765
PubChem ID
3639
Melting Point
268 - 270 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Hydrochlorothiazide is widely utilized in research focused on:

  • Hypertension Treatment: Commonly prescribed to manage high blood pressure, helping to reduce the risk of heart disease and stroke.
  • Edema Management: Used in patients with conditions like heart failure or liver cirrhosis to help reduce fluid retention, improving overall comfort and health.
  • Kidney Function Studies: Employed in clinical research to assess renal function and the effects of diuretics on electrolyte balance.
  • Combination Therapies: Often combined with other antihypertensive agents to enhance efficacy, providing a more comprehensive approach to blood pressure management.
  • Research in Cardiovascular Health: Investigated for its effects on cardiovascular health, contributing to studies aimed at understanding heart disease mechanisms.

Citations