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Catalog Number:
37922
CAS Number:
95058-81-4
Gemcitabine
Purity:
≥ 98% (HPLC)
Synonym(s):
2'-Deoxy-2',2'-difluorocytidine
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Product Information

Gemcitabine is a potent nucleoside analog that plays a crucial role in cancer treatment, particularly in the management of pancreatic, breast, and non-small cell lung cancers. This compound functions by inhibiting DNA synthesis, effectively halting the proliferation of cancer cells. Its unique structure, featuring difluorinated and hydroxymethyl groups, enhances its efficacy and selectivity, making it a preferred choice in chemotherapy regimens. Researchers and healthcare professionals appreciate Gemcitabine for its ability to improve patient outcomes, especially when used in combination with other therapeutic agents.

In addition to its established use in oncology, Gemcitabine is being explored for potential applications in other therapeutic areas, including viral infections and autoimmune diseases. Its versatility and effectiveness in targeting rapidly dividing cells make it a valuable tool in both clinical and research settings. By choosing Gemcitabine, professionals can leverage its unique properties to advance treatment strategies and improve patient care.

Synonyms
2'-Deoxy-2',2'-difluorocytidine
CAS Number
95058-81-4
Purity
≥ 98% (HPLC)
Molecular Formula
C9H11F2N3O4
Molecular Weight
263.2
MDL Number
MFCD00869720
PubChem ID
3461
Melting Point
217 - 222 °C
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]20D = 70 - 78 ° (C=1,MeOH)
Conditions
Store at < 0 °C
General Information
Synonyms
2'-Deoxy-2',2'-difluorocytidine
CAS Number
95058-81-4
Purity
≥ 98% (HPLC)
Molecular Formula
C9H11F2N3O4
Molecular Weight
263.2
MDL Number
MFCD00869720
PubChem ID
3461
Melting Point
217 - 222 °C
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]20D = 70 - 78 ° (C=1,MeOH)
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Gemcitabine is widely utilized in research focused on:

  • Cancer Treatment: Primarily used as a chemotherapy agent for various cancers, including pancreatic, breast, and lung cancer. Its effectiveness in inhibiting DNA synthesis makes it a critical component in treatment regimens.
  • Combination Therapies: Often combined with other chemotherapeutic agents to enhance efficacy. For instance, it is used alongside cisplatin for treating non-small cell lung cancer, improving overall treatment outcomes.
  • Research in Drug Resistance: Researchers study gemcitabine to understand mechanisms of drug resistance in cancer cells, aiding in the development of more effective therapies.
  • Pharmaceutical Development: Used as a benchmark in the development of new nucleoside analogs, helping pharmaceutical companies create innovative cancer treatments with improved efficacy and reduced side effects.
  • Clinical Trials: Frequently involved in clinical trials assessing new treatment combinations or delivery methods, providing valuable data that shapes future cancer therapies.

Citations