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Catalog Number:
37916
CAS Number:
29110-48-3
Guanfacine hydrochloride
Purity:
98 - 102% (Assay on dried basis)
Synonym(s):
N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride, N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
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Product Information

Guanfacine hydrochloride is a potent pharmaceutical compound primarily utilized in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension. This selective alpha-2 adrenergic agonist works by modulating neurotransmitter release in the brain, leading to improved focus and reduced impulsivity in ADHD patients. Its unique mechanism of action makes it a valuable alternative to traditional stimulant medications, offering a lower risk of abuse and side effects.

In addition to its psychiatric applications, guanfacine hydrochloride is also employed in managing high blood pressure, providing a dual benefit for patients with coexisting conditions. Researchers and healthcare professionals appreciate its efficacy and safety profile, making it a preferred choice in various therapeutic settings. With its ability to enhance cognitive function and emotional regulation, guanfacine hydrochloride stands out as a versatile compound in modern medicine.

Synonyms
N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride, N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
CAS Number
29110-48-3
Purity
98 - 102% (Assay on dried basis)
Molecular Formula
C9H9Cl2N3O·HCl
Molecular Weight
282.55
MDL Number
MFCD00798230
PubChem ID
71401
Melting Point
213 - 216 °C
Appearance
White to off-white crystalline powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride, N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
CAS Number
29110-48-3
Purity
98 - 102% (Assay on dried basis)
Molecular Formula
C9H9Cl2N3O·HCl
Molecular Weight
282.55
MDL Number
MFCD00798230
PubChem ID
71401
Melting Point
213 - 216 °C
Appearance
White to off-white crystalline powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Guanfacine hydrochloride is widely utilized in research focused on:

  • Attention Deficit Hyperactivity Disorder (ADHD) Treatment: This compound is primarily used in the management of ADHD, providing an alternative to stimulant medications. It helps improve attention and reduce impulsivity in children and adolescents.
  • Hypertension Management: Guanfacine hydrochloride is effective in lowering blood pressure, making it a valuable option for patients with hypertension, particularly those who may not tolerate other medications well.
  • Behavioral Disorders: It is also applied in treating behavioral issues associated with conditions like autism spectrum disorder, helping to manage symptoms such as irritability and aggression.
  • Research in Neuropharmacology: The compound is used in studies to understand its effects on the central nervous system, contributing to the development of new therapeutic strategies for various neurological conditions.
  • Comparative Effectiveness Studies: Guanfacine hydrochloride is often included in clinical trials assessing the efficacy of non-stimulant medications, providing insights into its benefits over traditional stimulant treatments.

Citations