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Catalog Number:
37913
CAS Number:
107007-99-8
Granisetron hydrochloride
Purity:
≥ 98% (Assay by titration , HPLC)
Synonym(s):
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Documents
$70.91 /200MG
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Product Information

Granisetron hydrochloride is a potent antiemetic agent widely utilized in the medical field to prevent nausea and vomiting associated with chemotherapy and radiotherapy. This compound acts as a selective serotonin 5-HT3 receptor antagonist, effectively blocking the action of serotonin, which is a key mediator in the vomiting reflex. Its high affinity for the 5-HT3 receptor makes it particularly effective in managing acute and delayed nausea, providing significant relief for patients undergoing cancer treatments.

In addition to its primary use in oncology, Granisetron hydrochloride has also found applications in postoperative care, where it helps mitigate nausea and vomiting following surgery. Its favorable pharmacokinetic profile allows for both oral and intravenous administration, making it versatile for various clinical settings. Researchers and healthcare professionals appreciate Granisetron hydrochloride for its efficacy and safety profile, which often leads to improved patient compliance and quality of life during challenging treatment regimens.

Synonyms
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
CAS Number
107007-99-8
Purity
≥ 98% (Assay by titration , HPLC)
Molecular Formula
C18H24N4O·HCl
Molecular Weight
348.88
MDL Number
MFCD01747034
PubChem ID
65264
Melting Point
292 °C (dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
CAS Number
107007-99-8
Purity
≥ 98% (Assay by titration , HPLC)
Molecular Formula
C18H24N4O·HCl
Molecular Weight
348.88
MDL Number
MFCD01747034
PubChem ID
65264
Melting Point
292 °C (dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Granisetron hydrochloride is widely utilized in research focused on:

  • Anti-Nausea Treatments: It is primarily used in oncology to prevent nausea and vomiting caused by chemotherapy, providing relief for patients undergoing cancer treatment.
  • Postoperative Care: This compound is effective in managing postoperative nausea and vomiting, improving recovery experiences for patients after surgery.
  • Clinical Trials: Researchers often use it in clinical studies to evaluate its effectiveness and safety in various patient populations, contributing to advancements in medical protocols.
  • Formulation Development: Granisetron hydrochloride is employed in the development of oral and injectable formulations, allowing for flexible administration routes tailored to patient needs.
  • Comparative Studies: It serves as a benchmark in studies comparing new antiemetic drugs, helping to establish efficacy and safety profiles against existing treatments.

Citations