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Catalog Number:
33642
CAS Number:
1172127-44-4
Fmoc-α-methyl-L-2-fluorophenylalanine
Purity:
≥ 99% (Chiral HPLC)
Synonym(s):
Fmoc-α-Me-L-Phe(2-F)-OH, Fmoc-(S)-2-amino-2-methyl-3-(2-fluorophenyl)propanoic acid
Documents
$60.00 /100MG
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Product Information

Fmoc-a-methyl-L-2-fluorophenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique fluorinated phenyl group, enhancing its properties for applications in medicinal chemistry and biochemistry. Its Fmoc (9-fluorenylmethyloxycarbonyl) protecting group allows for selective deprotection, making it an ideal choice for solid-phase peptide synthesis. Researchers appreciate its ability to introduce fluorine into peptides, which can improve binding affinity and bioactivity, making it valuable in the design of novel therapeutics.

In addition to its role in peptide synthesis, Fmoc-a-methyl-L-2-fluorophenylalanine is also explored in the development of fluorinated compounds for imaging applications in medical diagnostics. Its unique structure not only aids in the synthesis of complex peptides but also opens avenues for research in drug discovery and development. With its combination of stability, reactivity, and functional versatility, this compound is an essential tool for professionals in pharmaceutical and biochemical research.

Synonyms
Fmoc-α-Me-L-Phe(2-F)-OH, Fmoc-(S)-2-amino-2-methyl-3-(2-fluorophenyl)propanoic acid
CAS Number
1172127-44-4
Purity
≥ 99% (Chiral HPLC)
Molecular Formula
C25H22FNO4
Molecular Weight
419.45
MDL Number
MFCD17019320
PubChem ID
75057028
Appearance
White powder
Optical Rotation
[a]D20 = -29 ± 1 ° (C=1 in Ethanol)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Fmoc-α-Me-L-Phe(2-F)-OH, Fmoc-(S)-2-amino-2-methyl-3-(2-fluorophenyl)propanoic acid
CAS Number
1172127-44-4
Purity
≥ 99% (Chiral HPLC)
Molecular Formula
C25H22FNO4
Molecular Weight
419.45
MDL Number
MFCD17019320
PubChem ID
75057028
Appearance
White powder
Optical Rotation
[a]D20 = -29 ± 1 ° (C=1 in Ethanol)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-a-methyl-L-2-fluorophenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide structures with high purity.
  • Drug Development: Its unique fluorinated structure can enhance the pharmacological properties of peptides, making it valuable in the development of novel therapeutics with improved efficacy and selectivity.
  • Bioconjugation: The chemical can be used in bioconjugation techniques, facilitating the attachment of peptides to other biomolecules, which is essential in creating targeted drug delivery systems.
  • Research in Neuroscience: Due to its potential role in modulating receptor activity, this compound is useful in neuroscience research, particularly in studying neuropeptides and their effects on the nervous system.
  • Analytical Chemistry: It can be employed in analytical methods to characterize peptide structures, providing insights into their stability and interactions, which is crucial for quality control in pharmaceutical manufacturing.

Citations