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Catalog Number:
33573
N-Fmoc-7-methyl-D-tryptophan
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-D-Trp(7-Me)-OH
Documents
$120.58 /25MG
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Product Information

N-Fmoc-7-methyl-D-tryptophan is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound, known for its protective Fmoc (9-fluorenylmethoxycarbonyl) group, facilitates the selective modification of amino acids, making it an essential building block in the creation of complex peptides. Its unique 7-methyl substitution enhances the stability and solubility of peptides, which is crucial for various applications in pharmaceutical research and development. Researchers appreciate its role in improving the bioactivity and specificity of peptide-based therapeutics, particularly in the fields of oncology and neurobiology.

In addition to its applications in drug discovery, N-Fmoc-7-methyl-D-tryptophan is also employed in the synthesis of peptide libraries for high-throughput screening. Its compatibility with solid-phase peptide synthesis (SPPS) techniques allows for efficient and reproducible production of peptides, making it a preferred choice for researchers aiming to explore novel therapeutic candidates. The compound's favorable properties, such as its ease of handling and stability under standard laboratory conditions, further enhance its appeal in both academic and industrial settings.

Synonyms
Fmoc-D-Trp(7-Me)-OH
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C27H24N2O4
Molecular Weight
440.49
Appearance
White to off-white powder
Optical Rotation
[a]20D = -21 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Fmoc-D-Trp(7-Me)-OH
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C27H24N2O4
Molecular Weight
440.49
Appearance
White to off-white powder
Optical Rotation
[a]20D = -21 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

N-Fmoc-7-methyl-D-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the incorporation of modified amino acids.
  • Drug Development: It plays a role in the design of novel pharmaceuticals, especially in targeting specific receptors, enhancing the efficacy of drug candidates.
  • Bioconjugation: The compound is used in bioconjugation processes to attach biomolecules to surfaces or other molecules, improving the functionality of therapeutic agents.
  • Research in Neuroscience: It aids in studying serotonin receptors due to its structural similarity to tryptophan, providing insights into neurological pathways and potential treatments for mood disorders.
  • Protein Engineering: This chemical is valuable in modifying proteins to study structure-function relationships, helping researchers understand protein interactions and stability.

Citations