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Catalog Number:
33337
CAS Number:
1885-14-9
Phenyl chloroformate
Purity:
≥ 99% (Assay)
Synonym(s):
Chloroformic acid phenyl ester
Hazmat
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Product Information

Phenyl chloroformate is a versatile reagent widely utilized in organic synthesis, particularly in the formation of carbamates and esters. This compound serves as an effective acylating agent, making it invaluable in the pharmaceutical and agrochemical industries for the synthesis of various bioactive compounds. Its ability to introduce the phenyl carbonate moiety enhances the reactivity of substrates, facilitating the development of complex molecules. Researchers appreciate its role in the preparation of protected amino acids and in the derivatization of alcohols, which are crucial steps in the synthesis of pharmaceuticals and fine chemicals.

Moreover, phenyl chloroformate exhibits unique advantages over similar reagents, such as improved selectivity and reactivity, which can lead to higher yields in synthetic processes. Its application extends to the production of polycarbonate materials, showcasing its significance in materials science. With its broad range of applications and efficiency in chemical transformations, phenyl chloroformate remains an essential tool for chemists seeking to innovate and optimize their synthetic pathways.

Synonyms
Chloroformic acid phenyl ester
CAS Number
1885-14-9
Purity
≥ 99% (Assay)
Molecular Formula
C7H5ClO2
Molecular Weight
156.57
MDL Number
MFCD00000637
PubChem ID
15891
Density
1.24 g/cm3 (20 ?C)
Appearance
Clear colorless liquid
Boiling Point
74 - 75 ?C (Lit.)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Chloroformic acid phenyl ester
CAS Number
1885-14-9
Purity
≥ 99% (Assay)
Molecular Formula
C7H5ClO2
Molecular Weight
156.57
MDL Number
MFCD00000637
PubChem ID
15891
Density
1.24 g/cm3 (20 ?C)
Appearance
Clear colorless liquid
Boiling Point
74 - 75 ?C (Lit.)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Phenyl chloroformate is widely utilized in research focused on:

  • Synthesis of Carbamates: This compound serves as a key reagent in the synthesis of carbamate derivatives, which are important in the production of pesticides, pharmaceuticals, and herbicides.
  • Protecting Group in Organic Chemistry: It acts as a protecting group for amines during chemical reactions, allowing for selective modifications without affecting other functional groups.
  • Production of Isocyanates: Phenyl chloroformate is used in the preparation of isocyanates, which are essential intermediates in the manufacture of polyurethanes and other polymers.
  • Pharmaceutical Applications: This compound is involved in the development of various pharmaceutical agents, enhancing the efficacy and stability of drug formulations.
  • Analytical Chemistry: It is employed in the derivatization of alcohols and amines for improved detection and quantification in chromatographic techniques.

Citations