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Catalog Number:
32988
CAS Number:
1802078-36-9
DABCYL-(Asn670,Leu671-Amyloid β/A4 Protein Precursor770 667-675)-EDANS ammonium salt
Synonym(s):
DABCYL-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-EDANS ammonium salt, DABCYL-(Asn670,Leu671)-APP770 (667-675)-EDANS
Documents
$286.53 /1MG
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Product Information

DABCYL-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-EDANS ammonium salt is a specialized compound utilized primarily in biochemical research, particularly in the study of amyloid proteins associated with neurodegenerative diseases such as Alzheimer's. This compound serves as a fluorescent probe, allowing researchers to monitor protein interactions and conformational changes in real-time. Its unique structure, featuring both DABCYL and EDANS moieties, enables efficient energy transfer, making it an excellent choice for Förster Resonance Energy Transfer (FRET) applications.

In practical terms, this compound is invaluable for scientists investigating the aggregation of amyloid-beta peptides, providing insights into the mechanisms of plaque formation and potential therapeutic targets. Its ability to facilitate the visualization of protein dynamics enhances the understanding of disease progression and aids in the development of novel treatments. With its high sensitivity and specificity, DABCYL-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-EDANS ammonium salt stands out as a critical tool for researchers in the field of neurobiology.

Synonyms
DABCYL-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-EDANS ammonium salt, DABCYL-(Asn670,Leu671)-APP770 (667-675)-EDANS
CAS Number
1802078-36-9
Molecular Formula
C71H91N15O21S·NH3
Molecular Weight
1539.66
MDL Number
MFCD31692282
Conditions
Store at ≤ -10 °C
General Information
Synonyms
DABCYL-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-EDANS ammonium salt, DABCYL-(Asn670,Leu671)-APP770 (667-675)-EDANS
CAS Number
1802078-36-9
Molecular Formula
C71H91N15O21S·NH3
Molecular Weight
1539.66
MDL Number
MFCD31692282
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

DABCYL-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)-EDANS ammonium salt is widely utilized in research focused on:

  • Fluorescent Probes: This compound serves as a fluorescent marker in biochemical assays, allowing researchers to track protein interactions and cellular processes with high sensitivity.
  • Neuroscience Research: It is particularly valuable in studying amyloid-beta peptides, which are implicated in Alzheimer’s disease, helping scientists understand the disease mechanisms and potential therapeutic targets.
  • Drug Development: The compound aids in the screening of potential drug candidates by providing insights into the binding affinities of new molecules to amyloid proteins, streamlining the drug discovery process.
  • Biomarker Identification: It assists in identifying biomarkers for neurodegenerative diseases, enabling early diagnosis and monitoring of disease progression in clinical settings.
  • Protein Folding Studies: The chemical is used to investigate protein folding and misfolding, which are crucial for understanding various diseases and developing strategies for intervention.

Citations