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Catalog Number:
23077
CAS Number:
401514-72-5
Tris-succinimidyl aminotriacetate
Purity:
≥ 97% (NMR)
Synonym(s):
TSAT, NHS-3
Documents
$135.00 /25MG
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Product Information

Tris-succinimidyl aminotriacetate is a versatile crosslinking agent widely utilized in bioconjugation and protein labeling applications. This compound features three succinimidyl groups that facilitate the formation of stable amide bonds with primary amines, making it an ideal choice for researchers looking to create complex biomolecular constructs. Its unique structure allows for efficient conjugation to proteins, peptides, and other biomolecules, enhancing their stability and functionality.

In the field of drug development and diagnostics, Tris-succinimidyl aminotriacetate serves as a critical tool for the preparation of antibody-drug conjugates (ADCs) and targeted delivery systems. Its ability to form robust linkages ensures that therapeutic agents are effectively delivered to specific cells, improving treatment efficacy while minimizing side effects. Additionally, this compound is valuable in the development of biosensors and imaging agents, where precise labeling is essential for accurate detection and analysis. With its exceptional reactivity and ease of use, Tris-succinimidyl aminotriacetate stands out as a preferred choice for professionals seeking reliable and efficient bioconjugation solutions.

Synonyms
TSAT, NHS-3
CAS Number
401514-72-5
Purity
≥ 97% (NMR)
Molecular Formula
C18H18N4O12
Molecular Weight
482.36
MDL Number
MFCD02258953
PubChem ID
4150925
Melting Point
184 - 189 ºC
Appearance
White solid
Conditions
Store at ≤ -15 °
General Information
Synonyms
TSAT, NHS-3
CAS Number
401514-72-5
Purity
≥ 97% (NMR)
Molecular Formula
C18H18N4O12
Molecular Weight
482.36
MDL Number
MFCD02258953
PubChem ID
4150925
Melting Point
184 - 189 ºC
Appearance
White solid
Conditions
Store at ≤ -15 °
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tris-succinimidyl aminotriacetate is widely utilized in research focused on:

  • Bioconjugation: This compound is an effective crosslinker for attaching biomolecules, such as proteins and antibodies, to surfaces or other molecules, enhancing the development of targeted therapies and diagnostics.
  • Drug Delivery Systems: Its ability to form stable conjugates makes it valuable in creating drug delivery systems that improve the bioavailability and efficacy of therapeutic agents, particularly in cancer treatment.
  • Vaccine Development: The chemical is used to create conjugate vaccines by linking antigens to carrier proteins, which can boost immune responses and improve vaccine effectiveness.
  • Fluorescent Labeling: It serves as a tool for fluorescent labeling of biomolecules, aiding in imaging and tracking studies in cellular biology and molecular research.
  • Diagnostics: The compound is employed in the development of diagnostic assays, where it helps in the detection of specific biomolecules, enhancing the sensitivity and specificity of tests.

Citations