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Catalog Number:
22651
CAS Number:
193693-68-4
Fmoc-L-nipecotic acid
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Nip-OH, Fmoc-(Spiperidine-3-carboxylic acid
Documents
$58.39 /1G
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Product Information

Fmoc-L-nipecotic acid is a valuable compound widely utilized in the field of peptide synthesis and medicinal chemistry. This derivative of nipecotic acid features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during peptide assembly. Its unique structure allows for efficient incorporation into peptides, making it an ideal choice for researchers focused on developing novel therapeutics and studying neuroactive compounds.

The compound's properties, including its stability and compatibility with various coupling reagents, enhance its utility in solid-phase peptide synthesis (SPPS). Fmoc-L-nipecotic acid has been employed in the synthesis of bioactive peptides that target neurological pathways, showcasing its potential in drug discovery and development. Additionally, its ability to facilitate the formation of complex peptide structures positions it as a critical tool for researchers aiming to explore the therapeutic potential of peptide-based drugs.

Synonyms
Fmoc-L-Nip-OH, Fmoc-(Spiperidine-3-carboxylic acid
CAS Number
193693-68-4
Purity
≥ 99% (HPLC)
Molecular Formula
C21H21NO4
Molecular Weight
351.4
MDL Number
MFCD04112682
PubChem ID
2756141
Melting Point
165-170 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = +42 ± 3º (C=1 in MeOH or DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Nip-OH, Fmoc-(Spiperidine-3-carboxylic acid
CAS Number
193693-68-4
Purity
≥ 99% (HPLC)
Molecular Formula
C21H21NO4
Molecular Weight
351.4
MDL Number
MFCD04112682
PubChem ID
2756141
Melting Point
165-170 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = +42 ± 3º (C=1 in MeOH or DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-nipecotic acid is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups. This is crucial for creating complex peptides used in pharmaceuticals.
  • Drug Development: Its unique structure makes it valuable in the development of new drugs, particularly in the field of neuropharmacology, where it can be used to design compounds that target specific receptors in the brain.
  • Biochemical Research: Researchers use it to study the interactions between proteins and small molecules, helping to elucidate biological pathways and mechanisms, which is essential for advancing our understanding of diseases.
  • Material Science: Fmoc-L-nipecotic acid can be employed in the creation of novel materials, including hydrogels and polymers, which have applications in drug delivery systems and tissue engineering.
  • Analytical Chemistry: It is used as a standard in chromatographic techniques, aiding in the accurate analysis of complex mixtures in both academic and industrial laboratories.

Citations