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Catalog Number:
21942
CAS Number:
4354-76-1, 518-28-5
Podophyllotoxin
Purity:
≥ 98% (HPLC)
Synonym(s):
(-)-Podophyllotoxin, (5R,5aR,8aR,9R-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-5ah-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
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Product Information

Podophyllotoxin is a naturally occurring compound derived from the roots of the Podophyllum plant, known for its significant medicinal properties. This versatile chemical is primarily recognized for its role in the development of antiviral and anticancer therapies, particularly in the treatment of certain types of cancers and viral infections such as human papillomavirus (HPV). Its mechanism of action involves the inhibition of cell division, making it a valuable agent in oncology and virology research.

In addition to its therapeutic applications, Podophyllotoxin serves as a crucial intermediate in the synthesis of various pharmaceuticals, enhancing its relevance in drug development. Researchers and industry professionals appreciate its unique ability to selectively target cancer cells while minimizing damage to healthy tissues, which is a notable advantage over other chemotherapeutic agents. With ongoing studies exploring its potential in combination therapies, Podophyllotoxin continues to hold promise for advancing medical treatments and improving patient outcomes.

Synonyms
(-)-Podophyllotoxin, (5R,5aR,8aR,9R-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-5ah-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
CAS Number
4354-76-1, 518-28-5
Purity
≥ 98% (HPLC)
Molecular Formula
C22H22O8
Molecular Weight
414.41
MDL Number
MFCD00075290
PubChem ID
4865
Appearance
White powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
(-)-Podophyllotoxin, (5R,5aR,8aR,9R-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-5ah-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
CAS Number
4354-76-1, 518-28-5
Purity
≥ 98% (HPLC)
Molecular Formula
C22H22O8
Molecular Weight
414.41
MDL Number
MFCD00075290
PubChem ID
4865
Appearance
White powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Podophyllotoxin is widely utilized in research focused on:

  • Anticancer Treatments: This compound is a key ingredient in the formulation of chemotherapeutic agents, particularly for treating specific types of cancers such as testicular cancer and certain leukemias. Its ability to inhibit cell division makes it valuable in oncology.
  • Antiviral Applications: Podophyllotoxin has shown effectiveness against viral infections, particularly in the treatment of human papillomavirus (HPV). It is used in topical treatments to manage warts caused by HPV, providing a practical solution for patients.
  • Pharmaceutical Research: Researchers utilize this compound to develop new drugs and study its mechanisms of action. Its unique structure allows for modifications that can lead to more effective therapeutic agents, making it a focal point in drug discovery.
  • Natural Product Synthesis: As a naturally occurring compound, podophyllotoxin serves as a precursor for synthesizing other bioactive molecules. This is particularly relevant in the field of medicinal chemistry, where derivatives are explored for enhanced efficacy.
  • Botanical Studies: The compound is also significant in botanical research, especially in studying its effects on plant growth and development. This can lead to agricultural applications, such as developing pest-resistant crops.

Citations