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Catalog Number:
04991
CAS Number:
199006-54-7
Fmoc-4-methyl-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(4-Me)-OH, Fmoc-p-Me-L-Phe-OH
Documents
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Product Information

Fmoc-4-methyl-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, characterized by the presence of a 4-methylphenyl side chain, enhances the hydrophobic interactions, making it particularly valuable in the design of bioactive peptides and pharmaceuticals. Researchers appreciate its ability to improve the stability and solubility of peptides, facilitating the development of therapeutics with enhanced efficacy.

In addition to its applications in peptide synthesis, Fmoc-4-methyl-L-phenylalanine is also employed in the study of protein interactions and structure-function relationships. Its use in combinatorial chemistry allows for the rapid generation of peptide libraries, which can be screened for various biological activities. The compound's favorable properties make it an ideal choice for researchers looking to innovate in drug discovery and development, particularly in the fields of oncology and immunology, where peptide-based therapies are gaining traction.

Synonyms
Fmoc-L-Phe(4-Me)-OH, Fmoc-p-Me-L-Phe-OH
CAS Number
199006-54-7
Purity
≥ 98% (HPLC)
Molecular Formula
C25H23NO4
Molecular Weight
401.46
MDL Number
MFCD00270197
PubChem ID
5144280
Melting Point
165 - 175 ?C
Appearance
White powder
Optical Rotation
[a]20D = -31 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-Me)-OH, Fmoc-p-Me-L-Phe-OH
CAS Number
199006-54-7
Purity
≥ 98% (HPLC)
Molecular Formula
C25H23NO4
Molecular Weight
401.46
MDL Number
MFCD00270197
PubChem ID
5144280
Melting Point
165 - 175 ?C
Appearance
White powder
Optical Rotation
[a]20D = -31 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-methyl-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides efficiently.
  • Drug Development: Its unique properties make it valuable in the pharmaceutical industry for developing new drugs, particularly those targeting specific receptors or enzymes.
  • Bioconjugation: Fmoc-4-methyl-L-phenylalanine is used in bioconjugation processes, enabling the attachment of biomolecules to surfaces or other molecules, enhancing drug delivery systems.
  • Research in Neuroscience: This compound is important in studying neurotransmitter interactions, helping scientists understand brain functions and develop treatments for neurological disorders.
  • Custom Peptide Libraries: It is utilized for creating diverse peptide libraries for screening potential therapeutic candidates, facilitating advancements in personalized medicine.

Citations